Gestational Exposure to Soy Isoflavones and Epigenetic Regulation of Breast Cancer Risk
Abstract
The overarching challenge is to identify what makes the breast susceptible to cancer development, and more specifically, the mechanisms that link epigenetic silencing of the BRCA-1 gene to the development of triple-negative breast cancers (TNBC). The main purpose of this project is to examine whether the DNA methyltransferase (DNMT) inhibitor and soy isoflavone, genistein prevents CpG methylation of the BRCA-1 gene and development of TNBCs. Major findings: Preliminary data acquired through the support of this grant indicate that: 1) in cell culture experiments with ER-positive breast epithelial cells genistein exerted dose- and time dependent preventative effects on repression of BRCA-1 expression.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2016
- Accession Number
- AD1044336
Entities
People
- Donato F. Romagnolo
- Ornella I. Selmin
Organizations
- University of Arizona