microRNA in Cerebral Spinal Fluid as Biomarkers of Alzheimer's Disease Risk After Brain Injury

Abstract

A history of TBI increases the odds of developing AD by 2.5 times in the general population, and 4-6 times for military veterans. Although significant associations between mTBI and risk of AD have been observed, the precise mechanism by which TBI might lead to AD and/or AD-related symptoms are not yet understood. Histologically, AD is characterized by amyloid- and neurofibrillary protein aggregates, suggesting a loss of protein processing is a key feature of AD. MiRNAs are small non- coding RNA that regulate mRNA transcription, and may be a significant cause of protein dysregulation. To date, we have established molecular biology techniques that allow us to measure miRNA in CSF from living donors. We have established and validated a biostatistical pipeline to identify biomarker candidates from our assay. We are building a bioinformatics pipeline to associate altered miRNA signatures with predicted changes in mRNA regulation, that may link altered miRNA with AD-related pathologies.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2017
Accession Number
AD1044404

Entities

People

  • Joseph Quinn
  • Theresa A. Lusardi

Organizations

  • Oregon Health & Science University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Algorithms
  • Alzheimer Disease
  • Amplification
  • Biological Markers
  • Biology
  • Biomedical Information Systems
  • Brain Injuries
  • Computational Biology
  • Detection
  • Detectors
  • Diseases And Disorders
  • Medical Personnel
  • Pathology
  • Pipelines
  • Standards
  • Target Recognition

Fields of Study

  • Biology

Readers

  • Molecular Genetics
  • Traumatic Brain Injury (TBI) and Cognitive Aging in the Guam and Border Populations Affected by Alzheimer's Disease and Tau-Associated Dementias.