Targeting Discoidin Domain Receptors in Prostate Cancer

Abstract

We report the progress of our studies focusing on the Discoidin Domain Receptors (DDRs), a set of kinase receptors that signal in response to collagen in prostate cancer. The projects goal is to define the expression and therapeutic potential of DDRs in prostate cancer. During the second funding period, we concluded the immunohistochemical study of DDR1 expression in a 200 case Grade/Stage tissue microarray (TMA) using a highly specific antibody. These studies described the localization of DDR1 in normal vs. tumor tissues and the association between staining intensity and Gleason score. We found that DDR1 expression may be an early indicator of PCa development. DDR1 is over-expressed in tumor tissues among the low Gleason score patients but not in the high Gleason score patients. We continued the studies to test a highly specific DDR1 blocking antibody (Ab) in intraosseous growth of human PC3 prostate cancer cells.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2017
Accession Number
AD1044905

Entities

People

  • Rafael Fridman

Organizations

  • Wayne State University

Tags

DTIC Thesaurus Topics

  • Antibodies
  • Biological Staining And Labeling
  • Biomedical Research
  • Bone Fractures
  • Cell Line
  • Cells
  • Data Analysis
  • Diseases And Disorders
  • Intensity
  • Medical Personnel
  • Neoplasms
  • Prostate
  • Prostate Cancer
  • Regulations
  • Statistical Analysis
  • Tissues
  • X Rays

Fields of Study

  • Biology

Readers

  • Immunology
  • Molecular Biology and Genetics
  • Oncology and Biomarker-Based Cancer Detection.