Gene-Specific Demethylation as Targeted Therapy in MDS

Abstract

Myelodysplastic Syndromes (MDS) are a group of clonal hematopoietic disorders characterized by bone marrow failure and risk of progression to Acute Myeloid Leukemia (AML) in approximately 30 percent of the cases. Aberrant DNA methylation is considered a dominant mechanism for Tumor Suppressor Genes silencing during MDS evolution to AML, but the causes leading to aberrant DNA methylation remain elusive. This proposal builds on our recent discovery of a novel class of RNAs, the DiRs or DNMT1-interacting RNAs, involved in cell type-specific DNA methylation patterns. Based on these findings, we hypothesize that DNA methylation changes can be corrected by RNAs.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2017
Accession Number
AD1044910

Entities

People

  • Daniel G Tenen

Organizations

  • Beth Israel Deaconess Medical Center

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Bone Marrow
  • Bones
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Diseases And Disorders
  • Gene Expression
  • Hematologic Diseases
  • Leukemia
  • Lymphatic Diseases
  • Medical Personnel
  • Methylation
  • Neoplasms
  • Stem Cells
  • Suppressors

Fields of Study

  • Biology

Readers

  • Molecular and genetic basis of cancer.