CXXL 14 Blockade of CXCL12/CXCR4 Signaling in Prostate Cancer Bone Metastasis

Abstract

Bone metastasis is a common and unfortunate complication of advanced prostate cancer resulting in significant pain and fractures. The most devastating consequence, however, is that once the cancer has metastasized to bone, the disease is incurable. Up to 90% of men who succumb to prostate cancer have bone metastasis, which demonstrates the strong attraction of prostate cancer to bone. Chemokines are essential in cancer progression and metastasis. The chemokine CXCL14 was identified in a screen for factors that support prostate cancer bone metastasis. In a human prostate cancer tissue microarray, CXCL14 expression was found significantly greater in prostate cancer metastasis to bone compared to metastasis to other organs, suggesting that this chemokine has important effects that are specific to bone. The goal of this proposal is to understand the role of CXCL14 in the homing and progression of prostate cancer to bone.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2016
Accession Number
AD1045135

Entities

People

  • Gregory A. Clines

Organizations

  • Board of Regents of the University of Michigan

Tags

DTIC Thesaurus Topics

  • Albumins
  • Bone Marrow
  • Breast Cancer
  • Cancer
  • Cell Line
  • Cell Movement
  • Cell Physiological Processes
  • Cells
  • Cellular Structures
  • Culture Media
  • Culture Techniques
  • Department Of Defense
  • Internal Medicine
  • Metastasis
  • Neoplasms
  • Prostate Cancer
  • Tissues

Fields of Study

  • Medicine

Readers

  • Oncology (Cancer Research).