Curcumin Nanoparticle Therapy for Gulf War Illness

Abstract

The major goal of this project is to examine the efficacy of oral administration of curcumin (CUR) encapsulated biodegradable polymer nanosystems (nCUR) for alleviating cognitive, memory and mood impairments in a rat model of gulf war illness(GWI). Specific Aim 1 studies involve quantification of the efficacy of oral administration of different doses of nCUR for improving neurogenesis and suppressing inflammation and oxidative stress in the hippocampus. Specific Aim 2 studies will examine whether an apt dose of nCUR treatment (based on Specific Aim 1 studies) is efficient for alleviating cognitive, memory and mood impairments in GWI-rats, when treatment is commenced at an extended time-point (8-months) after exposure to GWIR chemicals and stress. During the past year, a set of experiments related to Specific Aim 1 studies was performed: (1) Exposure of rats to GWI related chemicals and moderate stress.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2017
Accession Number
AD1045514

Entities

People

  • Ashok K. Shetty

Organizations

  • Texas A&M University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Antigens
  • Cells
  • Complexometric Indicators
  • Confocal Microscopy
  • Hippocampus
  • Inflammation
  • Medical Personnel
  • Microscopes
  • Nanoparticles
  • Neurogenesis
  • Neuroglia
  • Neurons
  • Oxidative Stress
  • Persian Gulf Syndrome
  • Pesticides
  • Pyridostigmine Bromide
  • Stem Cells

Fields of Study

  • Psychology

Readers

  • Gulf War Illness and Chronic Multisymptom Illness in Veterans.
  • Neuroscience

Technology Areas

  • Biotechnology