High-Fidelity Design of Multimodal Restorative Interventions in Gulf War Illness
Abstract
Our objective is to further refine models of immune and endocrine regulatory dysfunction developed under W81XWH-10-1-0774 (Broderick PI) by improving fidelity of the timescale and drug action thereby translating previously idealized treatments into optimally beneficial low-risk drug re-purposing strategies that are immediately deployable as short exposure courses in phase-I clinical trials. With collaborating PI Dr. Whitley (CSU), we continue to make substantive progress towards project goals during this reporting period, specifically in the development of i) a formal algorithmic approach for direct integration of data with the contextual logic, ii) an algorithmic approach for model discovery and validation, and iii) redefinition of the treatment paradigm to focus on destabilization of illness and remission reachability.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2017
- Accession Number
- AD1045906
Entities
People
- Gordon Broderick
- M. A. Fletcher
- N. G. Klimas
- T. J. Craddock
Organizations
- Nova Southeastern University