Exploring Mechanisms Underlying Impaired Brain Function in Gulf War Illness through Advanced Network Analysis

Abstract

The goal of this project titled, Exploring Brain Mechanisms Underlying Gulf War Illness (GWI) with Advanced Network Analysis was to find brain mechanisms that underlie GWI. In pursuit of this goal, the tasks to be performed in Year 1 of this project were: 1) pre-processing of resting state fMRI (rsFMRI) data from 144 subjects; 2) performing group independent components analysis (ICA) on rsFMRI data of all subjects; and 3) labeling the resultant ICs of group ICA in terms of different brain functions they form constituent areas of. All these tasks were successfully accomplished in Year 1. Further, preliminary analysis of rsFMRI data from Control and Haley Syndrome 2 GWI subjects (in pursuant of aims of Year 2) revealed Syn2 exhibited clear deficits in brain communication in networks of the brain responsible for visual processing, mood regulation, motor coordination, sensory processing, and language command, but increased communication in networks related to pain perception during rest, consistent with self-reported symptoms.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2017
Accession Number
AD1046096

Entities

People

  • Kaundinya Gopinath

Organizations

  • Emory University

Tags

DTIC Thesaurus Topics

  • Algorithms
  • Biomedical Research
  • Brain
  • Contracts
  • Data Analysis
  • Department Of Defense
  • Department Of Veterans Affairs
  • Gulfs
  • High Resolution
  • Image Processing
  • Image Registration
  • Language
  • Medical Personnel
  • Mental Processes
  • Neurosciences
  • Pain
  • Persian Gulf Syndrome

Readers

  • Gulf War Illness and Chronic Multisymptom Illness in Veterans.
  • Team-Based Human-Centered Cognitive Task Decision Making and Information Performance.