Improving Ischemia Reperfusion Injury in Vascularized Composite Tissue Allotransplantation Via Histone Deacetylase Modulation

Abstract

This work proposes to investigate the impact of histone deacetylase (HDAC) drug inhibition or deletion on the tolerance of limb warm and cold ischemia reperfusion injury (IRI) in scenarios relevant to limb transplantation using mouse models for experimentation. Limitations in tolerated ischemia times limits the scope of donors that can be considered for any particular vascularized composite allotransplant (VCA) recipient. Mitigating IRI therapeutically would have significant impact on the applicability of VCA to military personnel suffering catastrophic limb or tissue loss.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2017
Accession Number
AD1046165

Entities

People

  • Matthew H. Levine

Organizations

  • University of Pennsylvania

Tags

DTIC Thesaurus Topics

  • Allografts
  • Biomedical Research
  • Blood
  • Data Acquisition
  • Enzyme Inhibitors
  • Governments
  • Health Services
  • Humanities
  • Inhibition
  • Inhibitors
  • Medical Personnel
  • Military Personnel
  • Pennsylvania
  • Professional Development
  • Transplants
  • Universities
  • Vascular Diseases

Fields of Study

  • Biology

Readers

  • Molecular Biology and Genetics
  • Trauma Surgery or Emergency Medicine.

Technology Areas

  • Biotechnology