Optimization of Delayed Tolerance Induction in Swine: A Clinically-Relevant Protocol for Immunosuppression-Free Vascularized Composite Allotransplantation

Abstract

This research project addresses the FY15 RTR Focus Areas of Understanding mechanisms of immune rejection and Immunomodulation approaches and mechanisms (e.g., tolerance induction, chimerism). Tolerance of kidney allografts has been achieved in nonhuman primates (NHPs) using a the delayed period protocol, i.e. combination of post transplant non-myeloablative conditioning and donor bone marrow transplantation four months later (DBMT).

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2017
Accession Number
AD1046206

Entities

People

  • Curtis L. Cetrulo, Jr

Organizations

  • Massachusetts General Hospital

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Allografts
  • Biomedical Research
  • Bone Marrow
  • Cells
  • Composite Materials
  • Department Of Defense
  • Health Services
  • Immunosuppression
  • Medical Personnel
  • Optimization
  • Professional Development
  • Surgery
  • Transplants
  • Upper Extremity

Readers

  • Neuroscience

Technology Areas

  • Biotechnology