Examination of plasma PON1 paraoxonase activity and genotype in Gulf War veterans

Abstract

The goal of this project is to evaluate the extent to which PON<sub1192>/Gulf War (GW)-related exposure interactions contribute to the risk for Gulf War Illness (GWI), as defined by the Centers for Disease Control and Prevention(CDC) and Kansas case definitions in a large sample of GW veterans. Specifically, we will: (1) determine the associations between GWI and GW-related exposures with the potential for cholinergic effects (e.g., personal pesticide use, exposure to OP nerve agents) in subgroups of veterans with different PON<sub1192> genotype. (2)determine the associations between GWI and each GW-related cholinergic exposure in subgroups of veterans with different PON1 activity levels and (3) calculate prevalence odds ratios for GWI/exposure associations separately for subgroups of veterans with different PON<sub1192> genotypes and PON1 activity levels.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2017
Accession Number
AD1046477

Entities

People

  • Linda L Chao

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Biomedical Research
  • Cellular Structures
  • Department Of Defense
  • Department Of Veterans Affairs
  • Diseases And Disorders
  • Genotypes
  • Governments
  • Health Care
  • Health Services
  • Institutional Review Board
  • Military History
  • Nerve Agents
  • Persian Gulf Syndrome
  • Pesticides
  • Professional Development
  • Surface Plasmon Resonance
  • Training

Readers

  • Gulf War Illness and Chronic Multisymptom Illness in Veterans.
  • Neurotoxicology