Modeling Marrow Failure and MDS for Novel Therapeutics
Abstract
Clonal evolution is a potentially life threatening long-term complication of inherited and acquired bone marrow failure (BMF) disorders. Cytogenetic clonal abnormalities develop in approximately 10 percent of patients with acquired aplastic anemia. The risk of early progression to myelodysplastic syndrome (MDS)and leukemia is also markedly elevated in patients with inherited marrow failure syndromes compared to age-matched controls. Prognosis of different clonal abnormalities is variable. Somatically acquired clonal deletions of one copy of chromosome 7 (monosomy 7) or part of the long arm of chromosome 7(del7q) are generally associated with a poor prognosis. Deletions involving chromosome 7 are frequently associated with therapy-related MDS, hypocellular MDS, MDS arising in children, and in MDS arising inpatients with marrow failure.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 2017
- Accession Number
- AD1046480
Entities
People
- Akiko Shimamura