Cell Based Meniscal Repair Using an Aligned Bioactive Nanofibrous Sheath

Abstract

The goal of this proposal is to develop a novel bio-activated, aligned, nanofibrous scaffold that will serve as mechanical and biological support for the repair of radial tears of the meniscus. The hypothesis is that scaffolds consisting of aligned polymeric fibers, which structurally and mechanically mimic tendon and fibrocartilage, may be applied as a patch in alignment with the fibers of the tissue to be repaired, i.e., the meniscus with radial tear, to strengthen mechanically the surgical meniscal repair, and to subsequently guide tissue regeneration, for example, by seeded tissue progenitor cells.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2017
Accession Number
AD1046566

Entities

People

  • Benjamin B Rothrauff
  • Rocky Tuan

Organizations

  • University of Pittsburgh

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Cartilage
  • Cells
  • Data Analysis
  • Fabrication
  • Fibers
  • Growth Factors
  • Histology
  • Materials
  • Materials Testing
  • Mechanical Properties
  • Medical Personnel
  • Nanofibers
  • Orientation (Direction)
  • Professional Development
  • Stem Cells
  • Students
  • Tissues

Fields of Study

  • Medicine

Readers

  • Reinforced Composite Materials
  • Trauma Surgery or Emergency Medicine.