Development of the Ovarian Cancer Cohort Consortium: Risk Factor Associations by Heterogeneity of Disease
Abstract
The objective of this application is to study the etiologic heterogeneity of ovarian cancer in multiple cohorts and to build the infrastructure of the Ovarian Cancer Cohort Consortium (OC3), an international consortium of cohort studies, to address scientific aims important for understanding ovarian cancer risk, early detection, and tumor heterogeneity that are only feasible in a consortium setting. Specifically we will examine associations of risk factors with invasive ovarian cancer, including (but not limited to) age, OCs, tubal ligation, parity, postmenopausal hormone use, family history of ovarian cancer, BMI, height, analgesic use, and lifetime ovulatory cycles, differ by histologic subtype, tumor dominance (as a surrogate for cell of origin), and tumor aggressiveness(tumors fatal within three years vs. all others). Then we will determine if risk prediction models for ovarian cancer can be improved by accounting for differential associations by cancer phenotype. In addition, the proposed efforts will create an infrastructure with a core dataset of important variables for ovarian cancer epidemiology that will be available for future efforts to study ovarian cancer risk, including projects that will use prospectively collected biological specimens. Currently, 27 cohorts have agreed to participate in the OC3, 25 of which have sent data that has been harmonized.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 2016
- Accession Number
- AD1046697
Entities
People
- Shelley S. Tworoger