Psychosocial Stress and Ovarian Cancer Risk: Metabolomics and Perceived Stress

Abstract

Mouse models suggest that chronic stress promotes ovarian tumorigenesis, but the relationship between stress and ovarian cancer has never been evaluated in humans. Over the last year of the grant, we published an analysis demonstrating that exposure to chronic stress leads to tumors that express the beta-2 adrenergic receptor, the signaling pathway identified in mouse models. We have also made progress developing a metabolomic signature of post-traumatic stress disorder (PTSD), a sentinel chronic stress condition. Overall, our continuing work on the role of stress in ovarian cancer development indicates that chronic stress may increase risk of developing ovarian cancer.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2017
Accession Number
AD1046699

Entities

People

  • Elizabeth M Poole

Organizations

  • Brigham and Women's Hospital

Tags

DTIC Thesaurus Topics

  • Anxiety Disorders
  • Biomedical Research
  • Cancer
  • Chemistry
  • Data Analysis
  • Department Of Defense
  • Diseases And Disorders
  • Gynecologic Cancers
  • Health Services
  • Medical Personnel
  • Metabolomics
  • Neoplasms
  • Ovarian Cancer
  • Social Psychology
  • Statistical Analysis
  • Traumatic Stress Disorder

Readers

  • Molecular Biology and Genetics
  • Psychological Intervention/Treatment for Stress, Anxiety, PTSD, and Related Emotional and Cognitive Health Symptoms.
  • Women's Health and Cancer Risk Research: African American Women and Pregnancy Outcomes.