Effects of Radiation on the Microbiota and Intestinal Inflammatory Disease

Abstract

In this annual report (covering initiating and collaborating PI projects) we report the completion of initial experiments investigating the effect of whole body and focal (GI tract)irradiation of mice on the bacterial and fungal microbiota. We have identified substantial changes in intestinal microbial communities induced by both types of radiation exposure. In particular, specific fungal community changes appear to be pronounced and relatively long-lived. As outlined in the project proposal, we are now embarking on experiments aimed a evaluating the effects of these changes on intestinal susceptibility to inflammatory disease.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2016
Accession Number
AD1046715

Entities

People

  • David M Underhill
  • Stephen Shiao

Organizations

  • Cedars-Sinai Medical Center

Tags

DTIC Thesaurus Topics

  • Body Weight
  • Breast Cancer
  • Cells
  • Cellular Structures
  • Colitis
  • Communities
  • Diseases And Disorders
  • Electronic Mail
  • Fungi
  • Gut Microbiome
  • Histology
  • Immune System
  • Lymphocytes
  • Medical Personnel
  • Microbiomes
  • Neoplasms
  • Radiation

Fields of Study

  • Biology

Readers

  • Gulf War Illness and Chronic Multisymptom Illness in Veterans.
  • Technical Research and Report Writing.

Technology Areas

  • Biotechnology