A Role of Plasminogen in Promoting the Immune Escape in Small Cell Lung Cancer

Abstract

This project tests the hypothesis that the plasminogen activation system is involved in immune escape and immune suppression in SCLC by developing a protective "coat" around the tumor cells, consisting of the plasmin, PAS and the fragments of the immunoglobulin G (IgG)s, that are cleaved by Plasmin in CH1-CH2 : CH2-CH3 domains of Fc fragments. The results of the study demonstrated that this protective coat is expressed on the surface of tumor cells, and that the level of its expression is significantly higher in metastatic tumor cells than in primary tumor cells and normal tissue cells. The results of this project have generated an important new fundamental knowledge about lung tumor biology. Further studies may lead to development of novel therapeutic approaches based on the dissociation of the protective "coat" from the tumor cell surface to improve the outcome of immunotherapy.

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Document Details

Document Type
Technical Report
Publication Date
Nov 01, 2016
Accession Number
AD1046718

Entities

People

  • Vera V. Levina

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Biomedical Research
  • Cancer
  • Department Of Defense
  • Information Operations
  • Lung Cancer
  • Maryland
  • Neoplasms
  • Plasminogen

Fields of Study

  • Biology

Readers

  • Cellular and Molecular Pathways of Apoptosis.
  • Immunology
  • Oncology

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech