A Novel Therapy for Inflammatory Bowel Disease-Dual Regulatory T-Cell Programming
Abstract
Inflammatory bowel disease (IBD) is a group of diseases that are conditions of chronic inflammation in the gastrointestinal tract(the GUT). Current therapies for IBD have a transient effect and are associated with significant side effects due to unintended immune suppression. Hence, a therapy that can lead to a more specific and lasting control of the gut inflammation is urgently needed. This study investigates a novel therapy that aims to induce gut-homing regulatory T (Treg) cells in the peripheral lymphoid tissues. We propose that the newly generated Treg cells can specifically home to and reinstate immune tolerance in the gut, thereby providing a long-lasting control of the chronic inflammation in the gut of IBD patients. This novel therapy is a dendritic cell (DC) that is engineered to de novo synthesize high concentrations of both the active vitamin D metabolite[1,25(OH)2D] and retinoid acid (RA). We hypothesize that such engineered DC can home to and interact with T cells in the peripheral lymphoid tissues where the DC-derived and de novo synthesized focally high concentrations of 1,25(OH)2D and RA can promote the induction of regulatory and gut-homing molecules respectively in the same T cell that subsequently differentiates into a gut-homing Treg cell. We will test this hypothesis using an IBD animal model, i.e. experimental colitis.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2017
- Accession Number
- AD1046756
Entities
People
- Xiaolei Tang
- Xuezhong Qin
- Yi Xu
Organizations
- Loma Linda University