Polymeric RNAi Microsponge Delivery Simultaneously Targeting Multiple Genes for Novel Pathway Inhibition of Ovarian Cancer

Abstract

The first year of this award included the following tasks. Major Task 1 IACUC and ACURO Approval. Subtask 1 IACUC Approval. Months: 1 - 3. Subtask 2 Acuro Approval. Months: 3 - 6. Milestone(s) Achieved: We obtained the necessary approvals for performing animal experiments. Major Task 2: Synthesis and in vitro testing of single component RNAi-MS. Subtask 1: Synthesis of single component RNAi-MS. Months: 1-3. Subtask 2: Target product inhibition by single component RNAi. Months: 1-3. Subtask 3: Single component RNAi-MS mediated inhibition of in vitro cancer cell tumorigenic behavior. Months:-4-8. This task is still ongoing we will accomplish by end of this no cost extension year, 7/31/2017. Major Task 3: Synthesis and in vitro testing of multiple component RNAi-MS. Months 4-12. This task is in progress.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2016
Accession Number
AD1046768

Entities

People

  • Michael Birrer

Organizations

  • Massachusetts General Hospital

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Cancer
  • Cells
  • Department Of Defense
  • Dyes
  • Genes
  • Health Services
  • Inhibition
  • Molecules
  • Neoplasms
  • Ovarian Cancer
  • Peptides
  • Polymers
  • Proteins
  • Targeting
  • Targets
  • Therapy

Fields of Study

  • Biology

Readers

  • Clinical Trial Research.
  • Molecular Biology and Genetics