Defining High-Risk Precursor Signaling to Advance Breast Cancer Risk Assessment and Prevention

Abstract

Making a major impact on the incidence and lethality of breast cancer will require a detailed understanding of the earliest tissue changes that ultimately drive the process of breast cancer development. There is no substitute for the ability to define and understand the early, pre-malignant changes as they occur in women who are breast cancer predisposed. One group of women at high breast cancer risk (up to 80 percent lifetime breast cancer risk) are those who have inherited mutations in the BRCA1 and BRCA2 genes. Currently, the only way these women can eliminate their risk is to undergo bilateral mastectomy before developing cancer. We have established an IRB-approved protocol that allows us to collect and analyze a portion of this tissue.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Mar 01, 2017
Accession Number
AD1046829

Entities

People

  • Leif W Ellisen

Organizations

  • Massachusetts General Hospital

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Cell Physiological Processes
  • Cells
  • Clinical Trials
  • Functional Analysis
  • Gene Expression
  • Genetic Phenomena
  • Health Services
  • Medical Personnel
  • Mutations
  • Neoplasms
  • Precursors
  • Risk
  • Risk Analysis
  • Stem Cells

Readers

  • Molecular and genetic basis of cancer.
  • Women's Health and Cancer Risk Research: African American Women and Pregnancy Outcomes.