Improving Diagnosis of Sepsis After Burn Injury Using a Portable Sepsis Alert System
Abstract
Background: Sepsis is the leading cause of death after significant burn injury. Severely burned patients (TBSA >20% ) have sepsis rates < 40 %. Early initiation of antibiotics within 1 hour of recognition of sepsis is the only factor associated with better survival. Diagnosis of sepsis after burn injury is not amenable to standard sepsis criteria. To address this problem, the American Burn Association developed specific criteria to prompt sepsis workup. Despite these guidelines, these findings can be subtle leading to delays in recognition of sepsis. Hypothesis: Best practice guidelines using new vital signs of heart rate variability, regional tissue oxygenation,and noninvasive cardiac output can diagnose burn sepsis earlier, reducing morbidity and mortality. Rationale: Heart Rate Variability (HRV), regional Tissue Oxygenation, and non-invasive Cardiac Output (CO), have shown promise indetecting sepsis in other patient populations. These modalities have not been evaluated for sepsis detection afterburn injury. Specific Aims/Study Design: 1. Prospectively collect traditional and new vital signs and compare thediagnostic accuracy, time to diagnosis, and prediction of outcome.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2016
- Accession Number
- AD1046850
Entities
People
- Ravi S. Radhakrishnan
Organizations
- University of Texas Medical Branch