Studying the Immunomodulatory Effects of Small Molecule Ras Inhibitors in Animal Models of Rheumatoid Arthritis

Abstract

During the first two year of the award, we made several high impact key observations:(I) Prophylactic treatment with Farnesylthiosalicylic acid (FTS), a first-in-class oral selective RAS inhibitor, provides a significant immunomodulatory effect in the rat adjuvant-induced arthritis (AIA) model by all outcome parameters(Clinical assessment and relevant laboratory/immunological/Molecular analyses). (II) Prophylactic dosing of FTS combined with methotrexate (MTX) provides a synergistic protective effect (~90 disease inhibition).(III) The FTS derivative, F-FTS, showed superior therapeutic clinical efficacy compared to FTS in the AIA model.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2016
Accession Number
AD1047106

Entities

People

  • Einav Vax
  • Galit E. Sfadia
  • Itamar Goldstein
  • Itzhak B. Moshe
  • Itzhak Ben Moshe
  • Morad Zayoud
  • Yoel Kloog

Organizations

  • Tel Aviv University

Tags

DTIC Thesaurus Topics

  • Arthritis
  • Autoimmune Diseases
  • Autoimmunity
  • Blood
  • Cells
  • Diseases And Disorders
  • Gene Expression
  • Inhibition
  • Inhibitors
  • Joints (Anatomy)
  • Lymphatic System
  • Lymphocytes
  • Medical Personnel
  • Molecules
  • Small Molecules
  • Statistical Analysis
  • Tissues

Fields of Study

  • Biology
  • Medicine

Readers

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