Direct Test for Neuroinflammation with [11C]DAP-713-PET Scanning

Abstract

This project concerns the non-invasive detection of inflammation in the brains of individuals suffering from the Gulf War Illness (GWI). We are using quantitative positron emission tomography (PET) using [11C]DPA-713 (DPA). DPA binds to the translocator protein (TSPO), which is located on the outer mitochondrial membrane and is an established biomarker of neuroinflammation. The study intends to enroll 10 patients and 10 appropriately matched healthy control subjects. The study is a collaboration between Johns Hopkins University and the University of Texas Southwestern Medical Center, where a carefully vetted population of individuals with GWI exists. PET imaging will be undertaken at Johns Hopkins.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2016
Accession Number
AD1047107

Entities

People

  • Jennifer Coughlin
  • Martin G. Pomper
  • Robert W. Haley
  • Yuchuan Wang

Organizations

  • Johns Hopkins University

Tags

DTIC Thesaurus Topics

  • Acquisition
  • Androgen Receptors
  • Biomedical Research
  • Cells
  • Department Of Defense
  • Detection
  • Diseases And Disorders
  • Intracellular Membranes
  • Lymphocytes
  • Magnetic Resonance
  • Magnetic Resonance Imaging
  • Medical Personnel
  • Parkinson'S Disease
  • Persian Gulf Syndrome
  • Positron Emissions
  • Scanning
  • Therapy

Readers

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