A Molecular Framework for Understanding DCIS

Abstract

This project centers on creating a molecular framework of DCIS (ductal carcinoma in situ). DCIS is considered to be the precursor to Invasive Ductal Carcinoma (IDC), the most common form of breast cancer. IDC accounts for 80% of all breast cancers, predominantly affecting women aged 55 and older; however, at least a third of women with IDC are diagnosed before they reach 55.Not all patients with DCIS will develop IDC however, we are looking for ways to better predict those patients that need life-saving treatment, and separate these from those patients who are less at risk. So far we have made over 1300 RNA libraries and 410 whole genome libraries and dissected material from 115 freshly frozen patient biopsies. The tissue included for RNA and DNA analysis DCIS, IDC, stroma adjacent to DCIS/IDC and normal tissue.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2017
Accession Number
AD1047308

Entities

People

  • Clare Rebbeck
  • Gregory Hannon

Organizations

  • University of Cambridge

Tags

DTIC Thesaurus Topics

  • Biomedical Information Systems
  • Biomedical Research
  • Breast Cancer
  • Carcinoma
  • Department Of Defense
  • Epithelium
  • Genetic Structures
  • Information Operations
  • Maryland
  • Materials
  • Medical Personnel
  • Neoplasms
  • Personal Information Managers
  • Professional Development
  • Quality Control
  • Tissue Banks
  • Tissues

Fields of Study

  • Medicine

Readers

  • Oncology and Biomarker-Based Cancer Detection.