Targeted Alteration of Dietary Omega 3 and Omega 6 Fatty Acids for the Treatment of Post Traumatic Headaches
Abstract
Post-traumatic headache (PTH) is a common problem in military personnel due to their high rate of traumatic brain injury (TBI). From a prior study in migraine we demonstrated that a high Omega-3/low Omega-6 (H3-L6) diet intervention reduced headache pain, altered circulating anti- and pro-nociceptive lipid mediators and their precursor fatty acids, reduced psychological distress and improved quality-of-life in a chronic headache population. We propose to carry out a 2-arm, parallel group, randomized, controlled 12-week dietary intervention trial to evaluate the biochemical effects and therapeutic efficacy of two dietary interventions (one high in Omega-3 and the other high in Omega-6, reflecting the usual US diet) in patients with PTH that are migrainous. We hypothesize that compared to the Control Diet (high Omega-6, low Omega-3), the H3-L6 intervention will produce significant increases in anti-nociceptive n-3 metabolites including 17-hydroxy DHA (Primary Biochemical Aim), and reductions in pro-nociceptive n-6 metabolites. Further, we hypothesize that compared to the Control Diet, the H3-L6 intervention will produce significant improvement in the Headache Impact Test(a headache-specific quality of life measure-Primary Clinical Outcome), mean total Headache Hours per day, and mean Severe Headache Hours per day.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2017
- Accession Number
- AD1047422
Entities
People
- Kimbra Kenney
Organizations
- Henry M. Jackson Foundation for the Advancement of Military Medicine