Enhancing the Prevention and Treatment of Orthopaedic Infections Associated with Traumatic Injury

Abstract

The goal of this project is to develop novel methods for the prevention and treatment of orthopaedic infections following traumatic injuries including those incurred on the battlefield. Using Staphylococcus aureus as a proof-of-principle pathogen based on its prominence as a cause of such infections and the severity of the infections its causes, we have undertaken studies to identify the most efficacious antibiotics and investigate the ability to conjugate these antibiotics to a novel bone targeting agent derived from a tetracycline moiety that binds hydroxyapatite.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2017
Accession Number
AD1047473

Entities

People

  • Mark S Smeltzer

Organizations

  • University of Arkansas for Medical Sciences

Tags

DTIC Thesaurus Topics

  • Albumins
  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Bacteria
  • Body Weight
  • Cell Membrane
  • Chemical Synthesis
  • Chemistry
  • Health Services
  • Infection
  • Medical Personnel
  • Microbiology

Fields of Study

  • Medicine

Readers

  • Oncology (Cancer Research).
  • Trauma Surgery or Emergency Medicine.