Early Recognition of Chronic Traumatic Encephalopathy Through FDDNP PET Imaging

Abstract

1. The PET biomarker, F-FDDNP (2-(1-{6-[(2-[F-18]fluoroethyl(methyl)amino]-2-naphthyl}ethylidene) malononitrile) [FDDNP] has shown sensitivity for in vivo detection of tau in addition to -sheet-containing brain amyloid neuroaggregates. Tau protein in a characteristic distribution is felt to be the cardinal pathologic feature of Chronic Traumatic Encephalopathy. This project will examine whether FDDNP PET imaging correlates with, and/or can predict, decline in cognitive function in those exposed to cumulative head trauma.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2017
Accession Number
AD1047642

Entities

People

  • Charles Bernick

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Biological Markers
  • Brain
  • Brain Injuries
  • Brain Stem
  • Chronic Encephalopathy
  • Data Analysis
  • Detection
  • Positron Emission Tomography
  • Positron Emissions
  • Recognition
  • Sensitivity
  • Technology Transfer

Fields of Study

  • Medicine

Readers

  • Traumatic Brain Injury (TBI) and Cognitive Aging in the Guam and Border Populations Affected by Alzheimer's Disease and Tau-Associated Dementias.
  • Vision Science/Vision Psychology/Cognitive Neuroscience.