Measuring Glial Metabolism in Repetitive Brain Trauma and Alzheimer's Disease

Abstract

The overall aim of the study is to better understand glial metabolism within the context of RBT and AD and its potential findings in veterans. While the delay in the IRB approval has been frustrating, it has allowed for the resolution of a number of technical issues. The most significant finding in this report is the availability of 7 Tesla system for increased signal to noise ratio and greater spectral dispersion that allows for more accurate detection of dynamic glutamate changes after infusion of 13C-acetate that will be specific to glial cells. Combined with the previously described improvements utilizing denoising algorithms, there will be a significant improvement of data quality.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2017
Accession Number
AD1047652

Entities

People

  • Alexander Lin

Tags

DTIC Thesaurus Topics

  • Acquisition
  • Algorithms
  • Alzheimer Disease
  • Availability
  • Brain Injuries
  • Cells
  • Department Of Defense
  • Detection
  • Diseases And Disorders
  • Glutamates
  • Health Services
  • Magnetic Resonance
  • Medical Personnel
  • Metabolism
  • Neurodegeneration
  • Neuroglia
  • Resonance

Readers

  • Image Processing and Computer Vision.
  • Medical Imaging.
  • Traumatic Brain Injury (TBI) and Cognitive Aging in the Guam and Border Populations Affected by Alzheimer's Disease and Tau-Associated Dementias.