Targeting Common but Complex Proteoglycans on Breast Cancer Cells and Stem Cells Using Evolutionary Refined Malaria Proteins

Abstract

In this project we have successfully produced recombinant VAR2CSA that binds with high affinity and high specificity to breast cancer cells and breast cancer tissue biopsies. We have demonstrated that the protein binds to distinct secondary modified proteoglycans exclusively present on breast cancer cells and that targeting these with recombinant VAR2CSAinterferes with key functions of the cancer cell like growth, migration and invasion. We have furthermore made proof-of-concept that a VAR2CSA protein conjugated with a toxin(hemiasterlin) efficiently eradicates breast cancer bone metastasis in a syngeneic mouse model. As such, all aims in this project has been fulfilled.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2017
Accession Number
AD1048115

Entities

People

  • Mads Daugaard

Organizations

  • University of British Columbia

Tags

DTIC Thesaurus Topics

  • Breast Cancer
  • Cancer
  • Carcinoma
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Health Services
  • Medical Personnel
  • Oncology
  • Social Media

Fields of Study

  • Biology

Readers

  • Oncology (Cancer Research).

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech