Hydroxocobalamin for Uncontrolled Hemorrhagic Shock Resuscitation in Swine (Sus scrofa)
Abstract
Background: Traumatic hemorrhage is a leading cause of death in military environments and causes 50% of military deaths. Groin hemorrhage is lethal and not amenable to tourniquet application. Objectives: To determine if HOC, a portable, safe and FDA approved drug, is effective in improving uncontrolled hemorrhagic shock and if it will improve systolic blood pressure in an uncontrolled hemorrhagic model without generating a rebleed with equal efficacy to Hextend (registered trademark). Methods: 16 animals anesthetized, instrumented. Femoral artery and vein were transected and allowed to bleed to sBP of 40mHg. Wound packed with QuickClot, 5 mins of manual pressure, and then randomly assigned to receive HOC or Hex. Observed for 2 hours. Results: The groups did not significantly differ on post-treatment blood loss, total blood loss, post-bleed MAP, and end-of-study MAP or SVO2. At 60 and 120 minutes, the Hex group had significantly higher CO compared to the HOC group and the HOC group had significantly higher SVR compared to the Hex group. We speculate that these differences in CO and SVR can be attributed to the mechanism of HOC.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 02, 2018
- Accession Number
- AD1048158
Entities
People
- Joseph K Maddry
- Maria G. Castaneda
- Normalynn Garrett
- Susan M. Boudreau
- Vikhyat S Bebarta
Organizations
- 59th Medical Wing