Intravenous versus intramuscular cobinamide compared to intravenous saline (control) in the treatment of acute, survivable, hydrogen sulfide toxicity in swine (Sus Scrofa).
Abstract
Background: Hydrogen sulfide (H2S) is one of the leading causes of unintentional workplace gas inhalation deaths. Significant exposures (50-400 ppm) may produce difficulty in breathing, agitation, confusion, nausea and vomiting, elevated blood pressure and loss of consciousness. Several potential antidotes are available for hydrogen sulfide poisoning, but none have been completely successful. We previously reported that intravenous cobinamide successfully rescues severely NaHS-poisoned swine from apnea in the absence of assisted ventilation; however, intramuscular administration is preferred in a workplace or mass casualty scenario.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 09, 2017
- Accession Number
- AD1048159
Entities
People
- Joseph K Maddry
- Maria G. Castaneda
- Normalynn Garrett
- Susan M. Boudreau
- Vikhyat S Bebarta
Organizations
- 59th Medical Wing