Novel Autoantibody Serum and Cerebrospinal Fluid Biomarkers in Veterans with Gulf War Illness

Abstract

The purpose of this project is to develop objective peripheral biomarkers for Gulf War Illness (GWI). We planned to determine circulating autoantibodies to ten proteins associated with the central nervous system in sera and plasma from a group of 250 Gulf War veterans with Gulf War Illness (GWI) and from 200 controls (100 healthy GW controls, 100 disease controls). Preliminary results using Western blot assay showed increased levels of autoantibodies in GWI cases compared to chronic fatigue syndrome, irritable bowel syndrome and low back pain controls. These results confirm continuing presence of autoantibodies against neural proteins in GW veterans and are in agreement with recent reports indicating that 26 years after the war, the health of veterans with GWI is not improving.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2017
Accession Number
AD1048274

Entities

People

  • Mohamed B. Abou-donia

Organizations

  • Duke University Hospital

Tags

DTIC Thesaurus Topics

  • Application Software
  • Biological Factors
  • Biological Markers
  • Biomedical Research
  • Blood
  • Brain Injuries
  • Cellular Structures
  • Chemistry
  • Coding
  • Colonic Diseases
  • Computer Programs
  • Copyrights
  • Data Analysis
  • Department Of Defense
  • Digital Information
  • Diseases And Disorders
  • Identities
  • Intellectual Property
  • Law
  • Medical Personnel
  • Metadata
  • Money
  • Nerve Agents
  • Nervous System
  • Notation
  • Pain
  • Parkinson'S Disease
  • Persian Gulf Syndrome
  • Photographic Materials
  • Photography
  • Public Health
  • Symbols
  • Toxicology
  • Trademarks
  • Transparencies
  • Word Processors

Fields of Study

  • Biology
  • Medicine

Readers

  • Gulf War Illness and Chronic Multisymptom Illness in Veterans.