Flexible Regenerative Nanoelectronics for Advanced Peripheral Neural Interfaces
Abstract
The overall objective of the proposed research is to develop a set of technologies to enable peripheral neural electrodes that have a high-density contact array, ultra-flexibility, and spatially defined biomaterials that promote neurovascular regeneration. The resulted regenerative neural electrode will be capable of selective interfacing and promote the ingrowth of neural and vascular tissues, which result in a seamless integration of peripheral nerves, vessels and electrode. We proposed the following related specific tasks to create advanced neural interfaces: Task 1. Design and fabrication of high-density ultra-flexible mesh electrodes. Task 2. Create and optimize patternable materials that can specifically induce neurovascular regeneration to stabilize electrode-nerve interaction. Task 3. Construct nerve guidance scaffolds comprising of embedded ultra-flexible mesh electrodes with defined pathways for neurogenesis/angiogenesis and test these scaffolds in a mouse subcutaneous implantation model and a rat sciatic nerve gap model.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2017
- Accession Number
- AD1048282
Entities
People
- Aaron B Baker
- Chong Xie
Organizations
- University of Texas at Austin