Understanding and Controlling Living/Inorganic Interfaces to Enable Reconfigurable Switchable Materials

Abstract

Results are highlighted for a 3-year study to study fundamental interactions between engineered E. coli cells and inorganic surfaces (gold and functionalized silica) to develop tailored, switchable bacterial adhesion to a target surface. This work includes protein engineering of multiple targets (FimH and eCPX), a variety of analytical techniques (including scanning electron microscopy and atomic force microscopy), theoretical models including multiphysics and multiscale treatments, as well as one of the first known studies of the role of environmental conditions and surface treatment on binding affinity.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 2018
Accession Number
AD1048432

Entities

People

  • Deborah Sarkes
  • Dimitra N Stratis-Cullum
  • Hong Dong
  • Jessica Terrell
  • Justin Jahnke
  • Margaret M. Hurley
  • Meagan Small
  • Nicole E. Zander

Organizations

  • United States Army Research Laboratory

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Adhesion
  • Biotechnology
  • Chemical Synthesis
  • Department Of Defense
  • Electrons
  • Engineering
  • Materials
  • Materials Science
  • Metallic Nanoparticles
  • Microbial Fuel Cells
  • Microscopy
  • Military Research
  • Molecular Dynamics
  • Surface Properties
  • Synthetic Biology
  • Systems Biology
  • Tooth Diseases

Readers

  • Computational Fluid Dynamics (CFD)
  • Molecular and Cellular Biochemistry
  • Nanoscale Plasmonic Nanotechnology

Technology Areas

  • Biotechnology
  • Microelectronics