Development of a PET Prostate-Specific Membrane Antigen Imaging Agent: Preclinical Translation for Future Clinical Application

Abstract

The overall objective of this research project is to collect chemistry and preclinical data on two promising new small-molecule peptidomimetic imaging agents labeled with positron emitting fluorine-18. These data will enable the filing of an exploratory IND (expIND; phase 0) application to the FDA by the end of the funding period. The small molecule imaging agents under study home to prostate specific membrane antigen (PSMA) that is prevalent on a majority of prostate cancers. The availability of these imaging agents will support diagnosis and staging of prostate cancer without the need for a biopsy as well as provide valuable information to guide therapeutic intervention and monitor the treatment outcome.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2017
Accession Number
AD1048460

Entities

People

  • Henry F VanBrocklin

Organizations

  • University of California, San Francisco

Tags

DTIC Thesaurus Topics

  • Availability
  • Chemistry
  • Department Of Defense
  • Elements
  • Fluorine
  • Membranes
  • Molecules
  • Neoplasms
  • Positrons
  • Prostate
  • Prostate Cancer
  • Quality Control
  • Schematic Diagrams
  • Small Molecules
  • Solid Phases
  • Standards
  • Translations

Fields of Study

  • Medicine

Readers

  • Medical Imaging.
  • Oncology (Cancer Research).