Effects of Radiation on the Microbiota and Intestinal Inflammatory Disease

Abstract

In this annual report (covering initiating and collaborating PI projects) we report the completion of experiments investigating the effect of inflammatory stimuli and focal irradiation of mice on the bacterial and fungal microbiota. We previously identified substantial changes in intestinal microbial communities induced by intestinal radiation exposure. Currently, we demonstrate that these changes correlate with increased sensitivity to inflammatory stimuli. As outlined in the project proposal, we are now in the midst of experiments aimed a evaluating the effects of radiation-induced changes in the microbiota on intestinal susceptibility to inflammatory disease.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2017
Accession Number
AD1048475

Entities

People

  • David M Underhill
  • Stephen Shiao

Organizations

  • Cedars-Sinai Medical Center

Tags

DTIC Thesaurus Topics

  • Bacteria
  • Body Weight
  • Cells
  • Cellular Structures
  • Colitis
  • Diseases And Disorders
  • Fungi
  • Gut Microbiome
  • Immune System
  • Lymphatic System
  • Lymphocytes
  • Medical Personnel
  • Microbiomes
  • Mononuclear Phagocyte System
  • Neoplasms
  • Radiation
  • Sensitivity

Fields of Study

  • Biology
  • Medicine

Readers

  • Microbial Pathology
  • Oncology
  • Vision Science/Vision Psychology/Cognitive Neuroscience.

Technology Areas

  • Biotechnology