Novel Small Molecule Inhibitor of Tyk2: Lucrative Therapeutic Target in Lupus

Abstract

This research project is directed at exploring the use of small molecule inhibitors of Tyk2 and Jak1 aimed at ameliorating the chronic inflammatory milieu and high titers of auto-antibodies in lupus, decrease disease symptoms and prolong survival in the (NZBxNZW)F1 mouse model of lupus. In our initial findings we report that treatment of lupus-prone (NZBxNZW)F1 mice with small molecule inhibitor of Tyk2/Jak1 significantly lowers the pathological auto-antibody production. The treatment also lead to a drop in the number of germinal centers in the spleen (NZBxNZW)F1 mice as well as a decrease in spleen weights. Over all, the treatment has shown potential for significantly improving the disease pathology in (NZBxNZW)F1 mouse model of lupus. We are in the process of performing experiments for the next phase of the proposal.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2017
Accession Number
AD1048482

Entities

People

  • Abhishek Trigunaite

Organizations

  • SRI International

Tags

DTIC Thesaurus Topics

  • Animal Diseases
  • Antibodies
  • Biomedical Research
  • Blood
  • Bone Marrow
  • Cells
  • Cytokines
  • Diseases And Disorders
  • Inhibitors
  • Lupus
  • Lymphatic System
  • Lymphocytes
  • Molecules
  • Production
  • Proteins
  • Small Molecules
  • Tissues

Fields of Study

  • Biology

Readers

  • Immunology
  • Neurological Diseases/Conditions/Disorders
  • Oncology (Cancer Research).