Novel Models to Study Effect of High-Altitude Hypoxic Exposure and Placental Insufficiency on Fetal Oxygen Metabolism and Congenital Heart Defects

Abstract

The idea for this proposal is that acute high altitude hypoxic exposure early in pregnancy during a critical period of organogenesis may critically reduce O2 transport to the fetus thereby causing Congenital Heart Defects in at-risk pregnancies. The first objective was to use a novel reporter of O2 concentrations, the ODDLuc mouse, to determine the dose-response relationship between hypoxia and reduced O2 delivery to the fetus. The second objective was to develop a novel mouse model of placental insufficiency to examine how maternal-fetal and gene-environment interactions may influence the effect of hypoxia on the developing heart.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2017
Accession Number
AD1048533

Entities

People

  • Steven P Fisher

Organizations

  • University of Maryland, Baltimore

Tags

DTIC Thesaurus Topics

  • Altitude
  • Biomedical Research
  • Congenital Heart Defects
  • Developmental Biology
  • Governments
  • High Altitude
  • Institutional Review Board
  • Local Governments
  • Medical Personnel
  • Patent Applications
  • Placenta
  • Pregnancy
  • Pregnancy Complications
  • Professional Development
  • Students
  • Technology Transfer
  • Training

Readers

  • Marine Mammal Biology
  • Molecular and Cellular Biology
  • Women's Health and Cancer Risk Research: African American Women and Pregnancy Outcomes.