Children's Hospital of Pittsburgh and Diabetes Institute of the Walter Reed Health Care System Genetic Screening in Diabetes: Candidate Gene Analysis for Diabetic Retinopathy
Abstract
The hypothesis to be tested was that there are allelic variations of some genes that make the development of diabetes-related complications more likely in patients who carry them than those who do not. The 3 major complications to be evaluated were diabetic nephropathy, diabetic neuropathy, and diabetic retinopathy. This was an observational study in which the investigators obtained DNA samples from the blood of patients with one or more of these complications and from as many their first-degree relatives as possible for testing in the laboratory of Dr. Massimo Trucco in the Rangos Research Center at the Children's Hospital of Pittsburgh (CHOP). Dr. Trucco is an internationally known immunologist and respected leader in genetic research in diabetes. He evaluated these samples by studying candidate genes selected a priori and testing for transmission/disequilibrium a standard for analysis of linkage between a candidate gene and a specific disease.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2010
- Accession Number
- AD1048558
Entities
People
- Robert A. Vigersky