Novel Epigenetic Reprogramming to Inhibit or Reverse EMT in Lung Cancer

Abstract

Carcinoma of the lung is the leading cause of cancer deaths in the US. The malignant properties of lung cancer, including invasion, metastasis and drug resistance, are driven inpart by the epithelial- mesenchymal transition (EMT), which makes this disease very difficult to treat. We hypothesized that TGF links NRP2-dependent signaling to upregulation of EZH2, an epigenetic modifier, and that EMT results from gene expression changes via a pathway of NRP2, ERK, ZEB1 and EZH2. We proposed to test the validity of this linkage, particularly the connection between NRP2, ZEB1 and EZH2, and to evaluate lung cancer susceptibilities to EZH2 inhibitors in combination with other epigenetic modifiers.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2017
Accession Number
AD1048721

Entities

People

  • Harry A. Drabkin

Organizations

  • Medical University of South Carolina

Tags

DTIC Thesaurus Topics

  • Biological Processes
  • Biomedical Research
  • Cancer
  • Cell Line
  • Data Analysis
  • Digital Data
  • Digital Information
  • Diseases And Disorders
  • Gene Expression
  • Governments
  • Inhibition
  • Inhibitors
  • Local Governments
  • Lung Cancer
  • Medical Personnel
  • Metadata
  • Neoplasms
  • Photographic Film
  • Photographic Materials
  • Photographic Recording Media
  • Photography
  • Rna Sequence Analysis
  • Small Molecules
  • South Carolina
  • Specialty Uses Of Chemicals
  • Transparencies

Fields of Study

  • Biology

Readers

  • Immunology and Pathology
  • Molecular Biology and Genetics
  • Molecular and genetic basis of cancer.