Molecular Innovations Toward Theranostics of Aggressive Prostate Cancer

Abstract

During the project, strategies for the preparation of new globular polymers (dendrimers) were introduced and methods for their rapid synthesis were pioneered. Both achievements address long-standing shortcomings of this field that have hindered translation to the clinic. Structure-activity relationships revealed design criteria for achieving high water solubility necessary for therapeutic application. Methods were surveyed for attaching varied functional groups including the therapeutic (through biolabile or stablelinkages) and imaging agent. This work led to the discovery of new hydrazone chemistry that offers broad application in drug/gene delivery. While the initially proposed multivalent therapeutics failed to recapitulate the activity of the lead compound, targeting prostate cancer cells with these constructs is now possible: a 60x increase in selectivity is seen. In aggregate, this opens opportunities for realizing new treatments.

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Document Details

Document Type
Technical Report
Publication Date
Nov 01, 2017
Accession Number
AD1048738

Entities

People

  • Eric E Simanek

Organizations

  • Texas Christian University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Chemical Analysis
  • Chemical Compounds
  • Chemical Synthesis
  • Chemistry
  • Mass Spectrometry
  • Materials Science
  • Metallic Nanoparticles
  • Molecular Dynamics
  • Organic Chemistry
  • Polymer Chemistry
  • Spectroscopy

Readers

  • Medical Imaging.
  • Military History / Militaries and War Studies
  • Molecular and Cellular Biochemistry