Optical Elastography of Systemic Sclerosis Skin
Abstract
Excessive accumulation of collagen and skin-thickening are hallmark features of Systemic sclerosis (SSc). The subjectiveness and the lack of precision associated with the Rodnan skin score, the current gold standard, calls for an improved detection method. Technologies such as magnetic resonance imaging, ultrasound, and optical coherence tomography have been tested in SSc, with varying success. Here, we advance a novel contact-independent noninvasive technique capable of micrometer/nanometer spatial resolution called optical coherence elastography (OCE) for monitoring skin disease in SSc. We have established the feasibility of using this technology to identify elasticity changes caused by SSc in vivo in murine skin. For the proposed human studies in Aim 2, the assessment of mRSS score and the OCE examination has been completed in 2participants (one patient with limited systemic sclerosis and one age-, race-, and gender-matched control). The generated raw data have been analyzed and shows promising preliminary results. We have been actively screening our clinic patients for additional participants. Four additional participants have been scheduled to participate in this study in December 2017. For the proposed murine studies in Aim 1, the animal model of SSc has been successfully re-established. In addition, animals are being scheduled for the proposed treatment and monitoring study.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2017
- Accession Number
- AD1048749
Entities
People
- Chandra Mohan
- Kirill V Larin
- Shervin Assassi
Organizations
- University of Houston