Furanyl Fatty Acid Inhibition of FABP5 as a Mechanism for Treatment and Prevention of Cancer

Abstract

We propose that inhibition of FABP5 represents a novel approach to diverting endogenous RA from pro-proliferative (PPAR ) to anti-proliferative (RAR) receptors, and further propose the use of furan-containing fatty acids as agents to target RA to RAR. We hypothesize that this pharmacologic inhibition will prevent the oncogenic effects of FABP5 overexpression in highly relevant breast cancer models that display a high ratio of FABP5:CRABP-II expression.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2017
Accession Number
AD1048754

Entities

People

  • Gregory P Tochtrop

Organizations

  • Case Western Reserve University

Tags

DTIC Thesaurus Topics

  • Breast Cancer
  • Carrier Proteins
  • Cells
  • Chemical Compounds
  • Chemical Synthesis
  • Electronic Mail
  • Fatty Acids
  • Inhibition
  • Lipids
  • Mass Spectra
  • Metabolism
  • Molecules
  • Neoplasms
  • Professional Development
  • Proteins
  • Small Molecules
  • Spectra

Readers

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  • Prostate Cancer Biology.