Magnetic Resonance Characterization of Axonal Response to Spinal Cord Injury

Abstract

This work studied the ability to detect and characterize damage to spinal cord axons and myelin after spinal cord injury. Studies conducted at Beth Israel Deaconess Medical Center, the University of Pennsylvania and Drexel University produced promising results for assessing axon fiber diameter distributions in vivo. An initial focus on q-space imaging (QSI) was quantitatively successful in animal models and a STEAM based high b value approach was successfully implemented in human subjects. Direct myelin imaging was shown to be quantitatively reliable using ultra short TE (UTE) and zero TE (ZTE) methods in specimens. Myelin imaging in human subjects was implemented using inhomogeneous magnetization transfer (ihMT) methods. Overall, the results suggest that MR can detect and quantify these aspects of spinal cord damage after trauma.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2014
Accession Number
AD1048974

Entities

People

  • David B. Hackney

Organizations

  • Beth Israel Deaconess Medical Center

Tags

DTIC Thesaurus Topics

  • Accuracy
  • Acquisition
  • Brain
  • Central Nervous System
  • Detection
  • Diameters
  • Diseases And Disorders
  • Equations
  • Frequency
  • Magnetic Resonance
  • Magnetization
  • Medical Personnel
  • Nervous System
  • Radio Frequency Pulses
  • Resonance
  • Spinal Cord
  • Spinal Injuries

Readers

  • Medical Imaging.
  • Neurotrauma and Rehabilitation Medicine.
  • Research Science/Academic Research

Technology Areas

  • Space