Branched Nerve Allografts to Improve Outcomes in Facial Composite Tissue Transplantation

Abstract

The gold standard for peripheral nerve gap repair remains the autologous nerve graft. However, off-the-shelf alternatives are appealing due to additional graft material, shorter operative times and avoidance of donor site morbidity. This study aims to evaluate the functional and histologic recovery of a novel branched a cellular nerve allograft (ANA) in a complex nerve defect. Yucatan miniature swine (n = 13) underwent transection of the left inferior division of the facial nerve containing the marginal mandibular (MMB) and cervical (C) nerve branches. The gap was addressed either by a sural nerve autograft, ANA, or a human xenograft with or without oral Tacrolimus. Electrophysiologic assessments were performed pre-operatively and at the study endpoint (24 weeks) to assess functional recovery using compound muscle action potential (CMAP) and histologic recovery by immunohistochemistry (IHC) using neurofilament and S100.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2017
Accession Number
AD1049907

Entities

People

  • Bohdan Pomahač
  • Mario Aycart

Tags

DTIC Thesaurus Topics

  • Acquisition
  • Allografts
  • Analysis Of Variance
  • Anatomy
  • Animals
  • Autografts
  • Autonomic Nervous System
  • Biomedical Research
  • Body Weight
  • Composite Materials
  • Data Science
  • Experimental Design
  • Health Services
  • Information Science
  • Laboratory Animals
  • Materials
  • Medical Personnel
  • Peripheral Nervous System
  • Recovery
  • Standards
  • Statistical Analysis
  • Surgery
  • Tissues
  • Transplantation
  • Transplants

Fields of Study

  • Medicine

Readers

  • Neuroscience
  • Oncology and Biomarker-Based Cancer Detection.
  • Trauma Surgery or Emergency Medicine.

Technology Areas

  • Biotechnology