Prevention of Lung Carcinogenesis by Suppressing Pathogenic CD4 T Cells
Abstract
(Lay Abstract) Chronic inflammation is increasingly recognized as an important factor that contributes to the development of a wide range of malignancies, including lung cancer. We recently found that T helper 17 (Th17) cells, a type of immune cell, is critical to inflammation. Th17 cells and their signature cytokine, interleukin-17 (IL-17), have been detected in various human cancers, but their function in tumor development remained unclear. Using genetically modified mice that develop a lung adenocarcinoma whose pathophysiology resembles that of the human disease, we demonstrated that IL-17 plays a critical pathogenic role in lung cancer development. Therefore, the mutagenesis-driven early inflammatory process in tumor is critical to lung cancer progression, and understanding the mechanisms underlying these actions will substantially advance our knowledge of cancer development and potentially lead to improved treatment strategies.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2017
- Accession Number
- AD1050130
Entities
People
- Seon H Chang
Organizations
- University of Texas at Austin