Molecular and Cellular Determinants of Malignant Transformation in Pulmonary Premalignancy
Abstract
During the first funding period we completed Major Tasks 1 and 2. The areas of interest were identified in 41 lung cancer patient and isolated by LCM. Genomic DNA was isolated from these areas and whole exome sequencing was performed. The data has been analyzed and the progression-associated mutations, as well as premalignant- and malignant-specific mutations, were identified. The mutational data was analyzed in the pathway context. Based on the mutational analysis, neoantigens were identified.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2017
- Accession Number
- AD1050188
Entities
People
- Kostyantyn Krysan
Organizations
- University of California