Development of Novel PD1/PD-L1 Antagonists Using Circular Cys-Knotted Micro Proteins

Abstract

During this first year we have constructed genetically-encoded libraries using the loops 1 and 5 of cyclotide MCoTI-I. We have also accomplished the design and expression of a FRET-based reporter to screen antagonists for the PD-1/PD-L1 complex.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2017
Accession Number
AD1050207

Entities

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  • Julio A Camarero
  • Nouri Neamati

Organizations

  • University of Michigan
  • University of Southern California

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