Tumor Slice Culture: A New Avatar in Personalized Oncology

Abstract

The project aims to improve our prediction of tumor response for patients with metastatic colorectal cancer (mCRC). Over the past year, we have been refining our tissue slice culture platform through standardization of protocol and modifications to culture conditions. We have developed a sensitivity index that allows for meaningful comparison between samples. Detailed analyses of tumor response to drugs are currently underway, along with advanced proteomic studies. Investigations using the slice culture to examine tumor response to immunotherapies have provided valuable insights towards novel strategies in the treatment of mCRC.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2017
Accession Number
AD1050209

Entities

People

  • Raymond Yeung

Organizations

  • University of Washington

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Cancer
  • Cell Physiological Processes
  • Cells
  • Colon Cancer
  • Computational Biology
  • Correlation Analysis
  • Immunotherapy
  • Inhibitors
  • Lymphocytes
  • Medical Personnel
  • Neoplasms
  • Oncology
  • Platforms
  • Sensitivity
  • Statistical Analysis
  • Therapy

Readers

  • Computational Modeling and Simulation
  • Oncology

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech