Therapeutic Sleep for Traumatic Brain Injury

Abstract

This proposal will test the hypothesis that correcting sleep disorders can have a therapeutic effect on Traumatic Brain Injury (TBI) The majority of TBI patients develop sleep disorders, a correlation that is extremely prevalent in military personnel. Here, we have developed a paradigm to induce TBI in Drosophila. TBI induction results in increased mortality, impaired climbing behavior, decreased/fragmented sleep and cell death. We also discovered a biphasic response in both impaired climbing behavior and altered gene expression in glia cells. We are currently testing whether sleep induction can restore these impairments.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2017
Accession Number
AD1050214

Entities

People

  • Bart van Alphen
  • Ravi Allada

Organizations

  • Northwestern University

Tags

DTIC Thesaurus Topics

  • Biological Sciences
  • Biomedical Research
  • Brain
  • Brain Injuries
  • Cell Physiological Processes
  • Cells
  • Climbing
  • Department Of Defense
  • Diptera
  • Diseases And Disorders
  • Drosophila
  • Experimental Design
  • Gene Expression
  • Information Operations
  • Intervention
  • Maryland
  • Mathematics
  • Medical Personnel
  • Military Personnel
  • Military Research
  • Professional Development
  • Sleep Deprivation
  • Sleep Disorders
  • Technology Transfer
  • Tissue Culture
  • Tissue Culture Cells

Fields of Study

  • Medicine

Readers

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  • Trauma Surgery or Emergency Medicine.